Exercise and Hawthorn Vinegar in a Streptozotocin-Induced Diabetic Rat Model: Glucose Metabolism, Lipid Profile, and Liver-Related Serum Biochemical Parameters

Miyaser Kaya; Mehmet İriadam; Hakim Çelik; Seyhan Taşkın

doi:10.5281/zenodo.22901007

Authors

Miyaser Kaya Harran Universitesi https://orcid.org/0000-0002-4126-0488
Mehmet İriadam Hacı Bayram Veli University https://orcid.org/0000-0002-9694-6014
Hakim Çelik Harran Üniversitesi https://orcid.org/0000-0002-7565-3394
Seyhan Taşkın Harran Üniversitesi https://orcid.org/0000-0002-3322-759X

DOI:

https://doi.org/10.5281/zenodo.22901007

Keywords:

Diabetes, Exercise, Hawthorn Vinegar, Lipid Profile, Streptozotocin

Abstract

Objective: The aim of the present study was to examine the effects of treadmill exercise, hawthorn vinegar, and their combination on body weight, glucose metabolism, lipid profile, and liver-related serum biochemical markers in streptozotocin (STZ)-induced diabetic rats.

Material and Methods: Forty-two male Wistar albino rats were allocated to healthy control (SK, n=6), diabetic control (DK, n=9), diabetes+exercise (DE, n=9), diabetes+hawthorn vinegar (DA, n=9), and diabetes+exercise+hawthorn vinegar (DEA, n=9) groups. Diabetes was induced with a single intraperitoneal dose of STZ (50 mg/kg). Exercise was performed for 30 minutes/day, five days/week for eight weeks, and hawthorn vinegar was administered by oral gavage at 1 mL/kg for the same period. Body weight and fasting blood glucose were monitored repeatedly; terminal serum markers were evaluated with multiple-comparison corrections.

Results: Significant group, time, and group×time effects were observed for body weight and serial fasting blood glucose. However, no intervention group differed significantly from the DK group at week 8. After false discovery rate correction, overall group differences remained significant for terminal glucose, insulin, AST, ALT, and albumin. All significant pairwise comparisons involved the SK group, and no intervention group differed from the DK group. Lipid markers showed no significant group differences.

Discussion and Conclusion: Although some numerical changes occurred in the intervention groups, none was statistically significant relative to the DK group. Under the present dose, duration, and model conditions, exercise, hawthorn vinegar, and their combination showed no superiority over diabetic control in glycemic, lipid, or liver-related serum outcomes.

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