Serum Albumin as a Biomarker Associated with Metabolic and Hematological Alterations in Geriatric Intensive Care Patients

Veysel Ağan

doi:10.5281/zenodo.22901229

Authors

Veysel Ağan Harran Üniversitesi https://orcid.org/0000-0003-0702-6249

DOI:

https://doi.org/10.5281/zenodo.22901229

Keywords:

Hypoalbuminemia, Geriatric intensive care, Logistic regression, Biomarkers

Abstract

Objective: This study aimed to investigate the relationships between serum albumin levels and demographic, hematological, and biochemical parameters in geriatric intensive care patients and to identify factors independently associated with hypoalbuminemia.

Material and Methods: This study included 172 patients admitted to the Intensive Care Unit of Harran University Hospital. Patients were divided into hypoalbuminemia and normal albumin groups. Demographic characteristics were compared with hematological and biochemical parameters, and multivariate logistic regression analysis was performed to determine the independent determinants of hypoalbuminemia.

Results: Hypoalbuminemia was present in 111 patients (64.5%). In the hypoalbuminemia group, hematocrit and serum calcium levels were significantly lower, while red blood cell distribution width values were higher. While gender distribution and serum urea levels showed significant differences between the groups, no significant differences were observed in age, glucose, CRP, HDL, and LDL levels. In multivariate analysis, low serum calcium and advanced age were independently associated with hypoalbuminemia.

Discussion and Conclusion: Low serum calcium levels and advanced age are independently associated with hypoalbuminemia in geriatric intensive care patients. It was concluded that serum albumin should also be considered when interpreting total serum calcium.

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