Magnezyumun İnsan Vücudu İçin Önemi ve Kardiyovasküler Hastaliklarla İlişkisi

Hacanlı Hacanlı

doi:10.5281/zenodo.10905672

Authors

Hacanlı Hacanlı

DOI:

https://doi.org/10.5281/zenodo.10905672

Keywords:

Magnesium, Electrolytes and Cardiovascular Diseases, Magnesium and Atrial Fibrillation

Abstract

Cardiovascular diseases include coronary heart disease, heart failure, heart attack and angina. The occurrence of these diseases is due to both cardiovascular risks and disorders in mineral levels. Magnesium, one of these important minerals, has an important place for living things. Magneyum is found in excess in cells. Because this mineral is involved in the maintenance of mitochondrial function, glycolysis, DNA, protein and ATP synthesis. In terms of cardiac functions, magnesium has activities such as calcium antagonist, ATP-dependent reaction regulator and cardiac rhythm regulator. It also acts as a cofactor of most enzymes. The relationship between magnesium and cardiovascular disease mortality has not been fully resolved. Hypomagnesemia, also known as magnesium deficiency, has been generally linked to cardiovascular disease and other cause-related mortality. However, the opposite of hypomagnesemia, hypermagnesemia, has also been shown to cause cardiovascular adverse events. Although magnesium has no direct function in the contraction mechanism, it affects calcium levels and causes a change in calcium levels. This change has been shown to regulate calcium-activated vascular smooth muscle contraction. Magnesium is associated with electrical conduction of the heart such as arrhythmia and atrial fibrillation. In this review, we aimed to investigate the relationship between magnesium and cardiovascular diseases.

References

Stefanadis C, Antoniou CK, Tsiachris D, Pietri P. Coronary atherosclerotic vulnerable plaque: current perspectives. J Am Heart Assoc. 2017;6(3):e005543.

Mohammadifard N, Humphries KH, Gotay C, Mena‐Sanchez G, Salas‐Salvado J, Esmaillzadeh A, et al. Trace minerals intake: risks and benefits for cardiovascular health. Crit Rev Food Sci Nutr. 2019;59(8):1334–1346.

Tangvoraphonkchai K, Davenport A. Magnesium and cardiovascular disease. Adv Chronic Kidney Dis. 2018;25(3):251–260.

Grober U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients. 2015;7(9):8199–8226.

Jahnen-Dechent J, Ketteler M. Magnesium basics. Clin. Kidney J. 2012;5(Suppl 1):i3–i14.

Nielsen FH, Johnson LAK. Data from controlled metabolicward studies provide guidance for the determination of status indicators and dietary requirements for magnesium. Biol Trace Elem Res. 2017;177(1):43-52.

Negru AG, Pastorcici A, Crisan S, Cismaru G, Popescu FG, Luca CT. The Role of Hypomagnesemia in Cardiac Arrhythmias: A Clinical Perspective. Biomedicines. 2022;10(10):2356.

Oost LJ, Tack CJ, de Baaij JHF. Hypomagnesemia and cardiovascular risk in type 2 diabetes. Endocr Rev. 2022;44(3):357–378.

Chrysant SG, Chrysant GS. Association of hypomagnesemia with cardiovascular diseases and hypertension. Int J Cardiol Hypertens. 2019;1:100005.

Vierling W, Liebscher DH, Micke O, von Ehrlich B, Kisters K. Magnesium deficiency and therapy in cardiac arrhythmias: Recommendations of the German Society for Magnesium Research. Dtsch. Med. Wochenschr. 2013;138(22):1165–1171.

Sözen T. Metabolik Kemik Hastalıkları. 2013 Ankara.17-57.

Wallach J. Interpretation of Diagnostic Tests: A synopsis of laboratory medicine fifth edition, Little, Brown and Company. 2000;pg.49.

Viering DHHM, de Baaij JHF, Walsh SB, Kleta R, Bockenhauer D. Detlef Bockenhauer Genetic causes of hypomagnesemia, a clinical overview Pediatr Nephrol. 2017;32(7):1123-1135.

Andreini C, Bertini I, Cavallaro G, Holliday GL, Thornton JM. Metal ions in biological catalysis: From enzyme databases to general principles. J. Biol. Inorg. Chem. 2008;13(8):1205–1218.

Del Gobbo LC, Imamura F, Wu JHY, de Oliveira Otto MC, Chiuve SE, Mozaffarian D. Circulating and Dietary Magnesium and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Prospective Studies. Am. J. Clin. Nutr. 2013;98(1):160–173.

Bechler K, Shkirkova K, Saver JL, Starkman S, Hamilton S, Liebeskind DS, et al. The Effect of Early Treatment with Intravenous Magnesium Sulfate on the Incidence of Cardiac Comorbidities in Hospitalized Stroke Patients. Cardiovasc. Ther. 2020;2020:1494506.

Altura BM, Altura BT, Gebrewold A, Ising H, Gunther T. Magnesium deficiency and hypertension: Correlation between magnesium-deficient diets and microcirculatory changes in situ. Science. 1984;223(4642):1315-7

Nielsen FH, Milne DB, Klevay LM, Gallagher S, Johnson L. Dietary Magnesium Deficiency Induces Heart Rhythm Changes, Impairs Glucose Tolerance, and Decreases Serum Cholesterol in Post Menopausal Women. J. Am. Coll. Nutr. 2007;26(2):121–132.

Cunha AR, D’El-Rei J, Medeiros F, Umbelino B, Oigman W, Touyz RM, et al. Oral Magnesium Supplementation Improves Endothelial Function and Attenuates Subclinical Atherosclerosis in Thiazide-Treated Hypertensive Women. J. Hypertens. 2017;35(1):89–97.

Fritzen R, Davies A, Veenhuizen M, Campbell M, Pitt SJ, Ajjan RA, et al. Magnesium Deficiency and Cardiometabolic Disease. Nutrients. 2023;15(10):2355.

Rosanoff A, Costello RB, Johnson GH. Effectively Prescribing Oral Magnesium Therapy for Hypertension: A Categorized Systematic Review of 49 Clinical Trials. Nutrients. 2021;13(1):195.

Veronese N, Demurtas J, Pesolillo G, Celotto S, Barnini T, Calusi G, et al. Magnesium and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational and intervention studies. Eur. J. Nutr. 2020;59(1):263–272.

Malinowska J, Małecka M, Ciepiela O. Variations in Magnesium Concentration Are Associated with Increased Mortality: Study in an Unselected Population of Hospitalized Patients. Nutrients. 2020;12(6):1836.

Khan AM, Lubitz SA, Sullivan LM, Sun JX, Levy D, Vasan RS, et al. Low serum magnesium and the development of atrial fibrillation in the community: The Framingham heart study. Circulation. 2013;127(1):33–38.

Salaminia S, Sayehmiri F, Angha P, Sayehmiri K, Motedayen M. Evaluating the Effect of Magnesium Supplementation and Cardiac Arrhythmias after Acute Coronary Syndrome: A Systematic Review and Meta-Analysis. BMC Cardiovasc. Disord. 2018;18(1):129.

Markovits N, Kurnik D, Halkin H, Margalit R, Bialik M, Lomnicky Y, et al. Database evaluation of the association between serum magnesium levels and the risk of atrial fibrillation in the community. Int J Cardiol. 2016:205:142-146.

Joris PJ, Plat J, Bakker SJ, Mensink RP. Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: results of a randomized, double-blind, placebo-controlled intervention trial. American Journal of Clinical Nutrition. 2016;103(5):1260–1266.

Zhao L, Hu M, Yang L, Xu H, Song W, Qian Y, et al. Quantitative association between serum/dietary magnesium and cardiovascular disease/coronary heart disease risk: a dose–response meta-analysis of prospective cohort studies. J Cardiovasc Pharmacol. 2019;74(6):516–27

Fang X, Wang K, Han D, He X, Wei J, Zhao L. et al. Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies. BMC Med. 2016;14(1):210.

Bagheri A, Naghshi S, Sadeghi O, Larijani B, Esmaillzadeh A. Total, Dietary, and Supplemental Magnesium Intakes and Risk of All-Cause, Cardiovascular, and Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies. Adv. Nutr. 2021;12(4):1196–1210.

Schwingshackl L, Boeing H, Stelmach-Mardas M, Gottschald M, Dietrich S, Hoffmann G, et al. Dietary supplements and risk of cause-specific death, cardiovascular disease, and cancer: a systematic review and meta-analysis of primary prevention trials. Adv Nutr. 2017;8(1):27–39.

Howitt SH, Grant SW, Campbell NG, Malagon I, McCollum C. Are Serum Potassium and Magnesium Levels Associated with Atrial Fibrillation After Cardiac Surgery?. J Cardiothorac Vasc Anesth. 2020;34(5):1152-1159.