Aminoasit ve Karnitinin Kardiyovasküler Hastaliklar Üzerine Etkileri

Ezhar Ersöz

doi:10.5281/zenodo.10905686

Authors

Ezhar Ersöz

DOI:

https://doi.org/10.5281/zenodo.10905686

Keywords:

Cardiovascular Diseases, Metabolites, Amino Acid, L-Carnitine

Abstract

Cardiovascular diseases are accompanied by disturbances in cardiac metabolism. Evaluation of metabolomics will enable us to learn more about the pathophysiological interactions of metabolites and disease states. Metabolomics is the detection, quantification and identification of small molecule metabolites consisting of lipids, carbohydrates, vitamins, hormones and other cell components in tissues, cells and physiological fluids for a certain period of time with the help of high additive technologies. Products such as micro molecules, peptides, oligonucleotides, sugars, nucleosides, organic acids, ketones, aldehydes, amines, amino acids, lipids, steroids, alkaloids are metabolites. Physiological amino acid concentrations depend on the functions of organs and pathological conditions may cause differences in metabolism. L-Carnitine, which also has antioxidant properties, is an amino acid derivative involved in the mitochondrial transfer of long-chain fatty acids and has important roles in lipid metabolism. This review summarises the current knowledge, perspectives and limitations of amino acids and carnitine in the diagnosis, prognosis and treatment of cardiovascular diseases such as heart failure, atherosclerosis, ischaemic and non-ischaemic cardiomyopathy

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