Koroner Arter Hastalarında Koroner Anjiyografi Öncesi ve Sonrası Karnitin Profilinin İncelenmesi: Karnitin ve Kardiyovasküler Hastalıklar

Adem İnco; Mehmet Salih Aydın; Yasemin Hacanlı

doi:10.5281/zenodo.12574936

Authors

Adem İnco Harran University https://orcid.org/0000-0002-7324-7202
Mehmet Salih Aydın Harran University https://orcid.org/0000-0002-6652-6035
Yasemin Hacanlı Harran University https://orcid.org/0000-0002-4427-8149

DOI:

https://doi.org/10.5281/zenodo.12574936

Keywords:

Coronary artery disease, Carnitine profile, Coronary Angiography, LCMS/MS

Abstract

Objective: Alterations in carnitine profile may play a role in the pathogenesis of cardiovascular diseases. This study was carried out to identify new markers that can be used in the diagnosis and treatment of cardiovascular diseases by comparing the free carnitine profile of coronary artery patients and normal individuals.

Material and Methods: In our study, 25 patients with coronary artery disease (treatment group) and 25 healthy volunteers (control group), totaling 50 individuals were included in the study. The carnitine profile in dry blood samples obtained from 25 individuals with coronary artery disease before and after coronary angiography was compared with the dry blood carnitine profile obtained from 25 healthy individuals. The free carnitine profile of the plasma samples was analyzed by LCMS8040. The results were evaluated statistically.

Results: In our study, 27 parameters in the carnitine profile (C0, C2, C3, C4, C4DC, C5, C5:1, C5OH, C5DC, C6, C6DC, C8, C8:1, C8DC, C10, C10:1, C10DC, C12, C14, C14:1, C14:2, C16, C16:1, C18, C18:1, C18:2, C18:1 OH) were examined in accordance with the LCMS/MS method. According to the results obtained; The values of C0, C2, C3, C4, C4DC, C5, C5:1, C5OH, C5OH, C14 and C16 parameters in the pre-angiography group of coronary artery patients were found to be higher than the control group. It was considered statistically significant (p<0.05).

Discussion and Conclusion: According to our results, we suggest that free carnitine profile has the potential to be used in the diagnosis and treatment of coronary artery disease.

Author Biography

Adem İnco, Harran University

He is working as a nurse at Harran University, Faculty of Medicine, Department of Pediatrics. Perfusion Department Master's degree graduate

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