Inflammatory Response in Cardiopulmonary Bypass Process

Gülşah Çelik Korhan

doi:10.5281/zenodo.14569321

Yazarlar

Gülşah Çelik Korhan Harran Üniversitesi https://orcid.org/0009-0001-2949-6287

DOI:

https://doi.org/10.5281/zenodo.14569321

Anahtar Kelimeler:

Kardiyopulmoner Baypas, İnflamatuvar Yanıt, Sitokin, İnflamasyon

Özet

Kardiyopulmoner baypas (KPB) ile yapılan kalp cerrahisi, çeşitli postoperatif komplikasyonların patogenezinde rol oynayan bir akut faz reaksiyonuna neden olur. Kalp cerrahisi hastalarında inflamasyon, trombin, kompleman, sitokinler, nötrofiller, adezyon molekülleri, mast hücreleri ve diğer inflamatuar mediatörlerin aktivasyonu, üretimi veya ekspresyonu gibi bir dizi yolak aracılığıyla karmaşık bir humoral ve hücresel etkileşim ağı aracılığıyla meydana gelir. Enflamatuar kaskadların fazlalığı nedeniyle koagülopati, solunum yetmezliği, miyokardiyal disfonksiyon, böbrek yetmezliği ve nörokognitif defisitler gibi çoklu organ sistemi disfonksiyonlarına yol açan derin amplifikasyon meydana gelir. Temas sisteminin aktivasyonu, endotoksemi, iskemi ve reperfüzyon hasarı ve cerrahi travma, KPB sonrası inflamasyonun potansiyel tetikleyicileridir. Pro- ve anti-inflamatuar mediatörler (sitokinler, adezyon molekülleri) arasındaki etkileşimde, hücre içi transkripsiyon faktörleri bu mediatörlerin salınımını düzenler. Bu derlemenin amacı, kardiyopulmoner baypas sırasında enflamatuar yanıtın nasıl işlediğini incelemek, bu sürecin vücutta bir bağışıklık yanıtını nasıl tetiklediğini, enflamasyonun hangi potansiyel komplikasyonlara yol açabileceğini ve bu komplikasyonların nasıl yönetilebileceğini anlamaktır.

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