Development Process and Clinical Application of Artificial Oxygen Carriers

Gülşah Çelik Korhan

doi:10.5281/zenodo.15775627

Yazarlar

Gülşah Çelik Korhan Harran Üniversitesi https://orcid.org/0009-0001-2949-6287

DOI:

https://doi.org/10.5281/zenodo.15775627

Anahtar Kelimeler:

Yapay oksijen taşıyıcılar, Hemoglobin bazlı taşıyıcılar, Perflorokarbon bazlı oksijen taşıyıcılar, Kök hücre tabanlı oksijen taşıyıcıları, O₂ mikro kabarcıkları.

Özet

Yapay oksijen taşıyıcıları; travma, cerrahi girişimler, doğum, mide ülserleri, hemorajik şok, vasküler rüptür ve ani kan hacmi kaybına neden olan diğer durumlarda, eritrositlere alternatif olarak geliştirilmiştir. Bu taşıyıcılar aracılığıyla terapötik oksijen iletimi, çeşitli hastalık modellerinin tedavisinde umut verici bir yaklaşım sunmaktadır. Ancak stabil, toksik olmayan ve immünolojik olarak inert yapay oksijen taşıyıcılarının geliştirilmesi hâlâ kritik bir ihtiyaçtır. Geliştirme süreci boyunca birçok zorlukla karşılaşılmış olmasına rağmen, bu taşıyıcıların elektif ve kardiyovasküler cerrahiler, hemorajik şok, dekompresyon hastalığı, akut inme, miyokard enfarktüsü, orak hücre krizi ve serebral hipoksi gibi çeşitli klinik durumlarda kullanımı gösterilmiştir.

Bu derleme, terapötik oksijen iletiminde kullanılan hemoglobin bazlı, perflorokarbon bazlı, kök hücre kaynaklı ve oksijen mikro/nano kabarcıklarına dayalı yapay oksijen taşıyıcılarının rollerini kapsamlı bir şekilde incelemektedir. Ayrıca bu yaklaşımlarla ilişkili olası yan etkiler ve sınırlılıklar, tamamlanmış ve devam eden çalışmalar ile güncel klinik gelişmeler ışığında değerlendirilmiştir. Ek olarak, ideal bir yapay oksijen taşıyıcısının geliştirilmesi için gerekli temel özellikler ve geleceğe yönelik çözüm önerileri sunularak mevcut literatüre katkı sağlanması ve alandaki ileri düzey araştırmalara rehberlik edilmesi amaçlanmaktadır.

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